The crash took place near the intersection of Randall Road and Red Gate Road in St. Charles Township around 3 p.m., according to the Kane County Sheriff's Dept.
Authorities said a grey sedan was traveling northbound on Randall Road when a minivan traveling southbound turned left onto Red Gate Road in front of him, causing a collision.
The sedan then veered off the roadway and struck a traffic signal pole on the passenger side.
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The sheriff's department said two men, ages 19 and 20, inside the grey sedan were transported to Delnor Hospital with serious injuries.
The 74-year-old driver of the minivan was treated at the scene, the sheriff's department said.
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It's not known if drugs or alcohol played a role in the crash at the time. Authorities continue to investigate.
Anyone who witnessed the crash or has any information about it is urged to contact the Kane County Sheriff's Office Investigations division at 630-444-1103.