The crash caused a full ground stop at RDU around 10:30 a.m. Wednesday that was lifted shortly before noon.
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Two people were inside the plane at the time of the crash. One of them was trapped for a short time before first responders were able to free them. Both were taken to the hospital for treatment after being removed from the aircraft. No other details were released on their condition.
UNC Health confirmed the plane was a UNC Air Operations medical plane. The two people onboard were a UNC physician and the pilot.
The small plane, a Socata TBM-850, is owned by Medical Air and was flying in from Wilmington.
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ABC Raleigh affiliate WTVD spoke with an airport employee about what he saw.
RDU employee talks about witnessing plane crash
A portion of runway near the plane did remain closed off.
This is a developing story. Check back for updates.