The truck, that was traveling north on Interstate 94, collided with a car near 103rd Street, causing the tanker to separate from the cab. The cab was hanging off a bridge, and the tanker landed on a ramp below.
The driver was in serious condition, but officials said he suffered non-life threatening injuries. He was taken to the University of Chicago Hospital.
The load carried by the truck was dry. It was contained, but officials have been working to clear the area.
All lanes on the northbound Bishop Ford reopened, but Stony Island Avenue southbound remained closed at 103rd Street Wednesday morning.