Aurora police responded to the 700 block of 5th Street after receiving multiple calls around 2:30 a.m., officials said.
"Officers responded to the scene and found three adult victims suffering from gunshot wounds," said Aurora Police Commander Jacks Fichtel. "All three people were transported to area hospitals."
Fichtel said one of those gunshot victims died from injuries.
Aurora Police hold briefing on Sunday morning shooting
"A short time later, we had two other people also walk into an area hospital with gunshot wounds," Fichtel said.
According to investigators,the pair was shot during the same incident.
Police said there were potential witnesses at the house. All four living gunshot victims have injuries that are not life-threatening, according to police.
Investigators said the shooting appears to be an isolated incident. Police believe there is no broader threat to the community.
Aurora police are calling for the public's help.
Anyone with information is asked to call Aurora Police's Investigations Division at 630-256-5500, or give information anonymously through Crime Stoppers at 630-892-1000.