The crash happened at about 5:48 a.m. on the Kennedy Expressway between North Avenue and Armitage Avenue on the Northwest Side.
Illinois State Police said the passenger vehicle was driving southbound on the northbound ramp when it struck a garbage truck head-on.
Crews closed all Kennedy Expressway lanes four about an hour and a half. IDOT told ABC7 there was a fuel spill on the expressway.
The wrong-way driver was taken to the hospital. No life-threatening injuries have been reported.
All lanes were back open by 7:15 a.m.
DEVELOPING NEWS | Baltimore bridge collapse: Rescue operation underway after people, vehicles plunge into water
Wrong-way driver crashes on OB Kennedy Expy. causing major delays: ISP