According to Chicago Fire Department officials, one vehicle was stalled in a lane when it was hit by several other vehicles.
A 39-year-old woman was rushed to the University of Chicago Medical Center, where she later died.
All local lanes were shut down at 59th Street to divert traffic off at 63rd Street.
Chicago police did not immediately provide additional information.
This is a developing story, and will be updated as more information is made available.