The shooting happened around 12:30 a.m. in the 300 block of Brunswick Avenue.
The victims include five men and four women. Two of the men are in critical condition.
A fifth woman was also injured in the chaos, but she was not hurt by gunfire, police say.
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Police are looking for a dark-colored SUV connected to the incident. There have been no arrests and no word on the identity of any suspect or suspects.
A news conference with the mayor and police director is expected at 4 p.m. Saturday.
A city councilman was outraged over the violence.
"Every time we get a break in the weather, a few in this city want to engage in gunplay. And I know that the police are working hard, they're working so hard to address this crime wave, but they need more resources," said Councilman Jerell Blakeley.
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"I call on the state troopers, I call on the National Guard. We need something in this city," Blakeley continued.
This is the second shooting in Trenton in less than a year that has injured multiple people.
Nearly 30 people were hurt in a shooting at the Art All Night Festival last June.
Bodycam video is released from Trenton arts festival shooting