The crash occurred at about 11:22 p.m. in the northbound lanes near Central Avenue, police said.
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Police said a box truck made an abrupt lane change to exit at Central Avenue and lost control, hitting a guardrail.
The driver was transported to a local hospital, where he was later pronounced dead, police said.
The Central Avenue exit ramp was closed down until about 1:06 a.m. as police investigating.
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Further details were not immediately available.
Stay tuned to ABC7Chicago.com and ABC7 Eyewitness News for more on this breaking news story.