Sheriff Johnny Williams said they believe John Hargrove, the father of 21-year-old Jada Swindell, stabbed her to death before shooting his 4-year old grandson and a 15-year old family friend, WTVD reported.
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The violence happened in Manson, North Carolina around 2:15 p.m. Monday.
Investigators arrived at the home to find two adults, a man and a woman, dead on the floor.
Two children, ages 15 and 4, were taken to the hospital with serious injuries. The 4-year-old later died during surgery at the hospital.
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Williams said Hargrove appears to have killed himself after the violent outburst. The 15-year-old girl remains in the hospital.
Neighbors told ABC11 they did not even know anyone lived in the home where the shooting happened.