Police said the victims were inside a residence in the 11700-block of South Princeton Avenue at about 12:04 a.m. when shots were fired from outside the home after a fight broke out.
A 42-year-old woman was shot in the face and a 20-year-old man was shot in the hand, arm and chest. Both were transported to Christ Medical Center in stable condition.
No one is in custody. Area South detectives are investigating.