According to police, around 1:27 a.m. the 23-year-old was sleeping in a second-floor room when an unknown person fired multiple shots outside the house in the 500 block of West 62nd Street.
A bullet entered the home and hit the woman in the right ankle, police said.
The woman was taken to St. Bernard Hospital, where her condition was stabilized, police said.
According to police, there were six other people inside the house at the time but no other injuries were reported.
Police said it's not clear who was the intended target of the shooting.
No suspects are in custody.
Area South detectives are investigating.