Police said the 15-year-old boy was shot in the lower back by someone in a silver sedan in the 1200-block of E. 63rd Street around 8:30 p.m.
The teen was driven to Jackson Park Hospital in critical condition, police said. He was later transferred to University of Chicago Comer Children's Hospital.
Police have not released any details about the circumstances of the shooting.
No one is in custody. Area One detectives are investigating.