The crash involving a semi and a car occurred at about 4 a.m. near 147th Street. The crash investigation shut down southbound I-57 for hours and shortly before noon, one southbound lane was opened.
Police said the driver of the car was traveling northbound in the southbound lanes when it collided with a semi-truck. The semi then crashed into a ditch, taking out a large stretch of guardrail in the process.
The drivers of both vehicles were transported to hospitals with non-life-threatening injuries, police said.