School spokeswoman Yuri Rodgers says that police believe the shooter is a former student, and that one victim is the night manager of Harkness Hall.
Officials do not know the motive for the shooting, reported around 1 a.m.
All students, faculty and staff were notified about the situation via text message and e-mail.
The school remained on lockdown Sunday morning while police investigated.
Hampton University is a private school with about 5,700 students.
On the Net: http://www.hamptonu.edu