The road has since been cleared and opened to traffic.
Officials say the semi-box trailer rear-ended a 2007 Ford utility van
Authorities say at approximately 5:35 a.m., the semi was northbound in the right lane on I-65 when it crested a hill when the driver realized that traffic in the right lane was slowed. The semi then hit the rear of the van in front of it.
The van spun out of control and went across all three lanes of traffic, hitting the concrete median wall. The semi over-corrected, causing what officials are calling an "improperly secured load of aluminum coils" to shift. The semi then rolled over onto its passenger side, blocking all three lanes of northbound traffic.
A third vehicle - a 2007 Chevrolet - was northbound in the left lane could not avoid the semi and hit the semi after it rolled.
The semi was carrying approximately 40,000 pounds of aluminum coils. Authorities say the load did not spill onto the road but did have to be unloaded before the semi could be righted.
The utility van was loaded with construction materials which were scattered over the northbound lanes. The Indiana Department of Transportation brought in a street sweeper to clean up nails and screws from the roadway.
All three drivers were taken to Saint Mary's Hospital in Hobart for minor injuries.
The northbound lanes of I-65 were closed and traffic was diverted off at 61st Avenue. All lanes were reopened about three hours later.