A new study finds these patients who chronically use drugs such as ibuprofen and naproxen might face an increased risk of suffering a heart attack or dying from cardiovascular causes.
This adds to concerns about the safety of these medications known as NSAIDs.
But, scientists say, it still doesn't mean the drugs themselves are to blame.
With the exception of aspirin, the safety of NSAIDs for people with heart disease has long been in question. Experts say people at high risk should take the lowest possible painkiller dose needed to ease symptoms for the shortest possible time.