The contest is called "Month at the Museum 2."
Just like last year, one lucky winner gets to call the museum home 24/7, for 30 days, and take home $10,000.
Judges combed through hundreds of applications and narrowed a list down to six finalists.
It's now up to the public to vote for their favorite.
You can find a link to vote daily by going to the Museum of Science and Industry website.
