Officials say the fire started at approximately 1:45 a.m. in the attic of a building in the 1600-block of North Central Park.
When firefighters arrived, they said they saw a man hanging out a window. That 43-year-old man was rescued and taken to the hospital, where he was listed in fair condition.
Firefighters also found a 40-year-old man dead inside the building.
The cause of the fire was under investigation Saturday.