The accident happened at Grand Avenue near Kostner just before 5:30 a.m. Sunday morning.
A 25-year-old victim was pronounced dead at the scene, while a 17-year-old was taken to Illinois Masonic Hospital.
Two other females refused medical treatment.
Police say the crash may have been the result of a car chase between several vehicles.
One of those vehicles fled the scene. Police are looking for the driver.