The breakup was first reported by People magazine. Publicist Jesse Derris confirmed the news and said no other details were available.
The brothers told People the breakup was unanimous and came after Nick Jonas told his brothers in a meeting earlier this month that he felt "trapped."
The New Jersey brothers formed the band in 2005 and built a fan base through their association with the Disney Channel.
The band had been scheduled to release its fifth album later this year.