Jenna Burleigh, 22, was last seen around 2 a.m. Thursday in the area of Pub Webb at 1527 Cecil B. Moore Avenue.
Overnight, police executed a search warrant at Burleigh's friend's home on the 1700-block of North 16th Street.
His roommate told police he found stains in certain areas of the home that looked as though someone had tried to clean up some blood.
Sources say Pennsylvania State Police picked the friend up at his grandmother's house in Scranton on Friday afternoon.
After questioning, police were able to obtain a search warrant for the off-campus home.
Homicide and crime scene units were seen taking evidence out of the home.
Police also brought in a cadaver dog, but it did not find anything.
So far, no charges have been filed.
Police released a surveillance photo of Burgleigh, which shows the clothing she was last seen wearing.
We need your help in finding Temple student Jenna Burleigh, who was last seen on August 31st at 2am. Please share any information. pic.twitter.com/eqRnyjcc3u— Temple Police (@TU_Police) September 1, 2017
Her family says Burleigh's phone is off and they have lost all communication. They say she is a commuter student who lives off-campus.
Anyone with information is asked to call Temple police at 215-204-1234 or their confidential tip line at 215-204-6493