Tamara Sword, 32, was caught in the middle of a gun fight near an Indianapolis nightclub in the 5800-block of Lafayette Road on Aug. 22, 2015. She was fatally shot while sitting in the passenger seat of a car.
Indianapolis police said Michael Edwards, 33, and Kenneth Jones, 28, were arrested Wednesday on warrants for murder and attempted murder.
Detectives serving a search warrant in the 5000-block of Clarkson Drive took the suspects into custody. Police also seized several weapons and a small amount of narcotics.
A hearing is scheduled Thursday.
Holmes has spent decades working to stop gun violence in Chicago. He said the break in his daughter's case is bittersweet.
"It's not a lot of relief because those individuals still have their life. They can walk. They can reach out and talk to their family. I can't talk to mine. The only thing I can do is hold on to my grandbaby," Holmes said.
Sword was the mother of five young children.