The large turkey was attempting to make flight across U.S. Highway 36 when it crashed into the 2007 Chevy Tahoe, which was traveling about 55 mph. The vehicle was heading westbound in the 1700-block of the highway, police said.
The bird, which was killed, ended up in the rear hatch of the vehicle. The driver sustained minor injuries from flying glass and debris.
There have been at least three similar incidents on Indiana roadways.
During the last week of March, turkeys crashed into police vehicles in both LaPorte County and near Scottsburg. That same week, a turkey went through the windshield of a rental vehicle of a New Jersey family visiting Notre Dame University, where the daughter was recently accepted.
In each incident, the vehicle passengers sustained non-life-threatening injuries.
The LaPorte County Sheriff's Office said incidents like this are rare, but wild turkeys are mating right now and the birds are in abundance ahead of hunting season starts.
Danville is located west of Indianapolis and about 180 miles southeast of Chicago.