The National Trust for Historic Preservation produced a time-lapse video over the course of the building's demolition, which took about a year and was completed in the fall of 2014. The group had hoped the building would be saved for its architectural attributes.
Watch a piece of Chicago's history come tumbling down
The hospital was open for more than 40 years, but was replaced by a newly constructed Prentice Women's Hospital a few blocks away.
"I was born there. At least it wasn't imploded. It seemed to go down with some dignity," said YouTube user Michele Hunter.
Northwestern plans to put a medical research center in its place. Preservationists had unsuccessfully fought to get the demolished building landmark status.