Police say the crash happened around 5 a.m. in the 200-block of West 71st Street.
Three people that were in a Ford Mustang had the most severe injuries, as two of them are in critical condition. One had to be airlifted to the hospital.
Two people that were in a Chevy are in fair condition and three passengers that were in a Nissan refused medical treatment.
No other details about the crash have been released.
PHOTOS: 3-car crash injures several in Englewood