Two vehicles were traveling northbound on I-57 near Halsted at 4:45 a.m. when someone in a green Chevy Suburban fired at the other vehicle, according to Illinois State Police.
Some of the vehicle's rear windows were shot out, but the female driver was not hurt, police said.
All lanes of I-57 were reopened as of 5:30 a.m., police said.
No one is in custody.
The driver said she was leaving the Red Diamonds night club when the shooting occurred. The two women in the car say they didn't know the shooter. They pulled over at a BP Amoco at 87th and State to talk to police.
The shooting temporarily shut down the nearby exit ramp from I-57.
The Sun-Times Media Wire contributed to this report.