Father Rene Robert, 71, was last seen on Sunday and reported missing two days later after he failed to show up to a church function, according to the St. Johns County Sheriff's Office.
Authorities said they now suspect foul play after Robert's vehicle, a four-door Toyota Corolla, was used in a high-speed pursuit Tuesday night.
When officers attempted to pull over a car matching Robert's description, the driver led deputies on a high-speed pursuit.
Authorities have identified the suspected driver as Steven James Murray, 28.
Investigators said Robert knew Murray through his ministry and had been providing help and services to him.
Anyone with any information concerning this investigation is asked to contact Major Crimes Detectives with the St. Johns County Sheriff's Office at (904) 824-8304.