The 23-year-old Bryant is the youngest player to lead the top-20 list, though youth is a theme among those that come off the racks the quickest.
San Francisco Giants pitcher Madison Bumgarner, who is 26, is No. 2, followed by his catcher Buster Posey (28), Los Angeles Dodgers pitcher Clayton Kershaw (27), Los Angeles Angels center fielder Mike Trout (24) and Washington Nationals right fielder Bryce Harper (22).
Thanks to Bryant -- and the team's first postseason berth since 2008 -- the sales of Cubs merchandisethis season are up 80 percent year versus a year ago. Cubs first baseman Anthony Rizzo joins Bryant in the top 10, coming in at No. 8.
Another team that has seen a huge boost in merchandise sales is the New York Mets, who won the NL East for the first time since 2006. Three Mets made the top 20 in jersey sales: pitcher Matt Harvey at No. 9; third baseman David Wright, who was injured for most of the season, at No. 11; and pitcher Jacob deGrom at No. 17.
Mets merchandise sales this season were up 95 percent, according to the league.
Noticeably absent from the top 20 was a representative from the New York Yankees. Derek Jeter, who retired last season, finished the second half of the season with the league's best-selling jersey.
Cubs' Bryant has MLB's top-selling jersey
Darren Rovell breaks down Major League Baseball's best-selling jersey list and discusses some surprise omissions.