The fire broke out sometime before 4 a.m. in the 1100-block of North Laramie Avenue in Chicago's Austin neighborhood, CFD said.
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One adult was taken to Stroger hospital in "yellow" condition, and another adult was taken to West Suburban Medical Center in "green" condition, according to Chicago fire officials.
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CFD did not immediately provide any additional information on the victims or regarding how the fire broke out.
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This is a developing story; check back with ABC Chicago for updates.