Leoist Jenkins, 67, of Sauk Village was driving the wrong way on the southbound Interstate 94 ramp to Interstate 80 in South Holland about 6 p.m. when he hit a semi head-on and then another vehicle, Illinois State Police and the Cook County Medical Examiner's Office said.
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He died just after 7 p.m. Tuesday.
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No other injuries were reported.
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The southbound I-94 ramp to eastbound I-80 was closed until about 11:30 p.m. for the investigation.