The fire took place at around 6 a.m. Wednesday morning at 3329 S. Morgan St.
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Video shows large flames shooting from the roof of the building, and heavy emergency responder presence.
The three-story building has businesses on the first floor and apartments above.
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Residents that were home at the time were able to escape safely.
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The Chicago Fire Department tweeted that human services were requested for residents of the building.
One firefighter was transported to a nearby hospital due to a minor injury that occurred while working to extinguish the fire.
The cause of the fire has not been released.