A group of about six burglars, two armed with guns, pried open the doors to the store in the 600-block of North Michigan Avenue at about 4:47 a.m., police said.
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They then entered the store and grabbed merchandise before fleeing in a pickup truck, police said.
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No injuries were reported and no one is in custody.
The incident marks the second time this week that the Burberry store was burglarized.
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Early Tuesday morning, police said five burglars broke in and stole merchandise from the store before driving off in a white SUV.
In November, four men stole handbags from the same store hurting two people as they got away.