The male driver of a sedan was making a U-turn in the 4600-block of South Cottage Grove Avenue just before 2:40 a.m. when he hit an unidentified male on a motorcycle, Chicago police said.
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The victim was taken to University of Chicago Medical Center, where he was pronounced dead.
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No one else was injured, and the Major Accidents Unit is investigating.
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No. 4 Cottage Grove buses are temporarily rerouted via Cottage Grove, 43rd Street, King Drive, 47th Street and Cottage Grove, due to street blockage, the CTA said.