The teen was in the 600-block of West 103rd Street in the city's Fernwood neighborhood just after 5:45 p.m. when CPD officers were traveling east in an unmarked squad car, police said.
The vehicle had its lights and sirens activated, as it was responding to an emergency, police said.
The girl was trying to cross the street, traveling north, when the vehicle hit her, according to CPD.
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She was taken to Comer Children's Hospital with non-life threatening injuries, police said.