CPD responded to a crash in which a van hit the center median about 1:15 a.m. in the 300-block of West 51st Street, in Fuller Park, CPD said.
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Chicago police said the vehicle had six people in it, who were taken to University of Chicago Medical Center and Provident Hospital of Cook County in fair condition.
A 17-year-old girl was pronounced deceased at University of Chicago, CPD said.
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The Cook County Medical Examiner's Office identified her as Cemya Williams of Chicago.
Police did not immediately provide additional information about how the crash took place.
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CPD was still investigating just before 6 a.m., and 51st was shut down at Shields Avenue.
Area One detectives are investigating.