CFD tweeted about the crash, which happened near the intersection of 71st Street and Dorchester Avenue in the city's Grand Crossing neighborhood, just before 11 p.m.
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One vehicle went left of the center line and hit another vehicle head-on, CFD said. A third vehicle then crashed from behind, according to Chicago fire officials.
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CFD said there were "several patients, some critical after heavy extrication."
At 11:35 p.m., the CTA tweeted that No. 71 71st Street/South Shore buses were rerouted due to street blockage.
The reroute ended about 6:15 a.m.
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This is a developing story; check back with ABC7 Chicago for updates.
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