Officers responded just after 2:50 a.m. to the 8800-block of South May Street and found an unidentified male victim, who had been hit.
After the vehicle came to a stop, the victim had suffered blunt force trauma to the body, and was taken to Advocate Christ Medical Center in Oak Lawn in critical condition. He later died, CPD said.
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No other details about the victim were immediately released, and it was not clear if any charges were pending.
The Major Accident Investigation Unit is investigating the incident.