Multiple ambulances were responding to the crash just after 11 a.m., CFD said on X, formerly known as Twitter.
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Four people were critically injured in the incident that involved two vehicles, CFD and state police said. Three were taken to Stroger Hospital, and one was taken to Northwestern Memorial Hospital, according to Chicago fire.
State police later said one person died.
CFD said the crash took place near Adams and Monroe streets.
Police said the Interstate 90 southbound exit to the eastbound Eisenhower Expressway was closed for investigation.
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It reopened about 2:45 p.m.
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It was not immediately clear how the crash occurred.