CFD transported a 32-year-old woman to University of Chicago Medical Center in serious condition from one vehicle and a 24-year-old man in critical condition to Northwestern Memorial Hospital from another vehicle after the incident.
The crash took place in the southbound lanes of the 1000-block of North DuSable Lake Shore Drive, near North Avenue and the Gold Coast, just after 4 a.m., CFD said.
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Chicago fire officials did not immediately have any additional information about what took place, and Chicago police did not immediately have details, either.
The crash was cleared by about 6 a.m., and traffic was no longer affected.