CFD crews responded to a two-car crash about 8:45 p.m. at Orleans and Ontario streets, near the Kennedy Expressway on-ramp.
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A 59-year-old woman was taken to Northwestern Memorial Hospital in critical condition, an 84-year-old woman was taken to Stroger Hospital in critical condition and an 81-year-old woman was taken to Stroger in critical condition, officials said.
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It was not immediately clear how the crash occurred.
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Chicago police are investigating.
This is a developing story; check back with ABC7 Chicago for updates.