Police said the suspects crashed a Nissan sedan into the front of the Neiman Marcus store in the 700-block of North Michigan Avenue at about 4:33 a.m.
The suspects were not able to make entry into the store and nothing was taken, police said.
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The suspects then got into three vehicles and fled east on Chicago Avenue, leaving the Nissan at the scene, police said.
No injuries were reported and no one is in custody. Area Three detectives are investigating.
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