The robbery took place at about 8:56 p.m. in the 1800-block of West North Avenue.
Police said a male in a black hoodie and a mask entered Zen Wine and Spirits, showed a handgun and announced a robbery.
Chicago police: Robbers target liquor stores, bar in West Town robbery spree
The 27-year-old clerk complied and was not injured police said. The robber then fled the scene, police said.
No one is in custody and Area 5 detectives are investigating.
INTERACTIVE SAFETY TRACKER Track crime and safety in your neighborhood