The fire broke out at about 10:43 p.m. in the 4200-block of South Ashland Avenue, Chicago police said.
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Massive flames and clouds of smoke could be seen billowing from the business, where CFD says a large amount of wooden pallets burned.
The company, called CAC Seating, makes furniture for restaurants, including booths, tables and chairs.
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The Chicago Fire Department said there was a large volume of pallets burning on the loading dock area.
Fire destroys South Side furniture business
The fire was struck Thursday morning and no injuries were reported. Firefighters remained on the scene Thursday morning to put out any hot spots.