The fire broke out at a home in the Burnside neighborhood's 1100 block of East 90th Street, the Chicago Fire Department said. Fire officials responded to the fire and reports of a person trapped inside at 7:25 p.m.
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A man was transported to Advocate Trinity Hospital, fire officials said. He was pronounced dead.
The fire was put out and the cause is being investigated, CFD said. Authorities have not provided further information about the fire.
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