Police officers and firefighters responded to a residential fire in the 7500-block of South DuSable Lake Shore Drive at about 1:35 a.m.
Firefighters extinguished the fire and found a 67-year-old man laying on the floor unresponsive, police said.
Chicago fire: Retired nurse, 71, killed, husband critically hurt in Rosemoor house blaze, CFD says
Police said the man had second-degree burns and smoke inhalation and was pronounced dead on the scene. Authorities have not released the man's identity.
Investigators determined the cause of the fire was accidental, police said.