The man was found unresponsive in the 4600-block of South California Avenue just after 6:40 a.m., CPD said.
An unknown vehicle appeared to have hit him, and he was pronounced dead on the scene in Brighton Park, according to CPD.
Neither the man's identity nor a description of a suspect vehicle was immediately provided.
No one was in custody later Wednesday, and area detectives are investigating.
A 42-year-old woman was killed in a separate hit-and-run crash Monday night in West Garfield Park. That suspect also remains at large.
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