The woman was standing in the road about 1:45 a.m. in the 4700-block of West Arthington Street when a white SUV hit her and then kept driving, Chicago police said.
Chicago fire crews took her to Stroger Hospital, where she is listed in critical condition.
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No one was in custody later Monday morning.
The Major Accidents Unit is investigating the incident.
This is a developing story; check back with ABC7 Chicago for updates.