CPD responded to the 5200-block of West North Avenue in the city's North Austin neighborhood about 12:55 a.m. for a report of a crash.
When police arrived, they found a vehicle had hit a 38-year-old man, CPD said.
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He was taken to Mt. Sinai Hospital, where he died just after 1:35 a.m.
Police said a silver sedan driving east on North Avenue hit the man, stopped momentarily and then drove away.
CPD said the man was not in a crosswalk.
No one was in custody later Sunday morning, and Area Five detectives are investigating.
The Cook County Medical Examiner's Office identified the man killed as Ulysses Coleman of Chicago.