A CFD spokesperson said a man was shot on northbound Interstate 94 near 103rd Street in the city's Pullman neighborhood at about 2:50 p.m.
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He was taken to University of Chicago Medical Center in critical condition, fire officials said. He later died at the hospital, the Cook County Medical Examiner's Office said.
SEE ALSO: 13-year-old boy critically injured in Burnside shooting: Chicago police
Illinois State Police were still on the scene investigating about 4:30 p.m., blocking the northbound exit ramp just south of 103rd to Stony Island Avenue.
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It was not immediately clear how the shooting occurred.
A white sedan with its windows blown out and glass shattered could be seen in the area.
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