Chicago police said it happened at about 12:04 a.m. in the 4600 block of South Prairie. That's in the Bronzeville neighborhood.
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Police said a 20-year-old man was approached by another man who demanded his belongings and shot him.
The victim was taken to the University of Chicago Hospital with two gunshot wounds to the knee, police said. He was last listed in good condition.
No one is in custody.
Area One Detectives are investigating.